Overdiagnosed and oversupplemented: the iatrogenic rise of vitamin D toxicity
Authors' conclusion
Rapid test growth paralleled a rightward shift and expanding high-concentration tail
Study context
- Population
- Adult serum 25(OH)D results, Barcelona tertiary hospital (2020–2025), VDSCP-certified immunoassay25(OH)D results
- Participants
- 185,604 participants
- Outcome
- Trends in 25(OH)D testing and concentrations, 2020-2025
Methodological detailssingle-centre, tertiary hospital, laboratory database analysis
- Single-centre
- Tertiary hospital
- Laboratory database analysis
Main finding
As reported in the abstract
Increase in annual testing
54.1%
Median 25(OH)D rose
25.3 to 28.6 ng/mL
Very high results (>100 ng/mL) more than doubled
31 [0.14%] to 108 [0.31%]
Total very high results
393
Observational data: associations, not effects.
Further findings
Calcifediol use documented
- Hypervitaminosis D patients with available supplementation data
- 183/201 (91.0%)
- Hypercalcemic cases
- 12/14 (85.7%)
- Often in short-interval dosing regimens
Safety
Hypercalcemia (albumin-corrected calcium >10.5 mg/dL) among results >100 ng/mL
- Hypercalcemia
- 14/324 (4.3%)
- Calcium available
- 324/393
Original publication
Overdiagnosed and oversupplemented: the iatrogenic rise of vitamin D toxicity. Eur J Endocrinol. Published 18 May 2026. doi:10.
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