Ovarian stimulation does not induce thyrotropin receptor autoantibodies in women with thyroid autoimmunity
Study context
- Population
- Women of subfertile couples with thyroid autoimmunity (TAI) undergoing OS for assisted reproductive technology (ART); mean (SD) age 38.8 (±3.2) yearseleven cycles in TAI
- Participants
- 10 vs 1
- Exposure
- Before vs after ovarian stimulation
- TAIn = 10
- Without TAIn = 1
- Outcome
- Presence of binding and functional (stimulating or blocking) TSH-R-Ab, five assays
- Follow-up
- Before and after OS
Main finding
As reported in the abstract
TSH-R-Ab · before or after OS
- TSH-R-Ab in all samples below the cut-off of the immunoassay and four bioassays before or after OS
Observational data: associations, not effects.
Further findings
Oestradiol during OS
- Oestradiol increased from 40 (26-56) ng/L to 963 (383-5095) ng/L
- P < 0.01
Cumulative OS dose
- Median (range) cumulative OS dose, IU/L
- 1413 (613-2925)
Baseline thyroid tests · median baseline
- Median TSH, mIU/L
- 2.33 (2.23-2.61)
- Median free thyroxine, pmol/L
- 16.8 (14.4-18.5)
- Median TPOAb, kIU/L
- 152 (86-326)
Original publication
Ovarian stimulation does not induce thyrotropin receptor autoantibodies in women with thyroid autoimmunity. Eur J Endocrinol. Published 30 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →