Once‐weekly insulin icodec versus once‐daily insulin degludec for type 2 diabetes in China: A cost‐utility and budget impact analysis
Authors' conclusion
Within the current reimbursement context in China, once-weekly icodec is a dominant strategy compared with degludec, offering greater health benefits at a lower cost for patients with type 2 diabetes and generating potential annual savings.
Study context
- Population
- Simulated insulin-naive Chinese patients with T2D, based on the Chinese subgroup of the ONWARDS 3 trial
- Exposure
- Once-weekly insulin icodec vs once-daily insulin degludec
- Outcome
- Long-term cost-utility (lifetime costs and health outcomes)
- Follow-up
- 40-year time horizon
Methodological detailsIHE Diabetes Cohort Model, 40-year time horizon, 5% annual discount rate, Chinese healthcare system perspective, one-way and probabilistic sensitivity analyses
- IHE Diabetes Cohort Model
- 40-year time horizon
- 5% annual discount rate
- Chinese healthcare system perspective
- One-way and probabilistic sensitivity analyses
Main finding
As reported in the abstract
Lifetime cost-utility, icodec vs degludec
Life expectancy increase with icodec
0.025 years
QALY gain with icodec
0.216 QALYs
Cost reduction with icodec
$1450.73
Observational data: associations, not effects.
Further findings
One-way sensitivity analyses
- Incremental quality-adjusted life-years (QALYs) range
- 0.065 to 0.464
- Cost savings range
- $ 265.84 to $4166.30
Probabilistic sensitivity analysis
- Mean QALY gain
- 0.212 QALYs
- Mean cost reduction
- $1320.46
Budget impact analysis: annual savings after icodec reimbursement · 2025, 2026, 2027
- Annual savings 2025
- $1.17 million
- Annual savings 2026
- $2.35 million
- Annual savings 2027
- $2.58 million
Original publication
Once‐weekly insulin icodec versus once‐daily insulin degludec for type 2 diabetes in China: A cost‐utility and budget impact analysis. Diabetes Obes Metab. Published 6 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →