Omega-3 Polyunsaturated Fatty Acids And Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort
Authors' conclusion
These findings will add to the limited evidence on the potential role n-3 PUFAs have in the prevention and management of AT inflammation in humans and may help inform future interventions targeting chronic inflammation at the level of AT.
Study context
- Population
- Participants in the PROMISE cohort; Adipose tissue (AT) inflammation biomarkers measured at baseline and up to 2 follow-up visits; n-3 polyunsaturated fatty acids (PUFAs) measured at baseline in 4 serum lipid fractions
- Participants
- 474 participants
- Exposure
- Higher vs lower baseline circulating n-3 PUFA proportions
- Outcome
- Longitudinal change in circulating biomarkers of AT inflammation
- Follow-up
- Baseline and up to 2 visits
Methodological detailslongitudinal, generalized estimating equations, fully adjusted for covariates
- Longitudinal
- Generalized estimating equations
- Fully adjusted for covariates
Main finding
As reported in the abstract
Longitudinal change in AT inflammation biomarkers
- Higher baseline EPA, n-3 docosapentaenoic acid and docosahexaenoic acid in total serum significantly inversely associated with longitudinal change in soluble CD163
- all P < .05
- n-3 docosapentaenoic acid and docosahexaenoic acid significantly positively associated with longitudinal change in adiponectin
- P < .05
Observational data: associations, not effects.
Original publication
Omega-3 Polyunsaturated Fatty Acids And Adipose Tissue Inflammation: Longitudinal Analysis in the PROMISE Cohort. J Clin Endocrinol Metab. Published 29 June 2024. doi:10.
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