Observational Study of the Impact of Infusion Set Replacement in Insulin Pump Users on Glycemic Management
Authors' conclusion
Our evaluation of the real-world impact of prolonged infusion set use revealed an association between longer use and worsening of glycemic management.
Study context
- Population
- Individuals with T1D on insulin pump therapy with real-time continuous glucose monitoring (CGM); logs from Medtronic CareLink system; median age 40 (IQR 32–51) years, median BMI 22.5 (21.2–23.8) kg/m²
- Participants
- 45 individuals
- Exposure
- Infusion set use day 4 vs day 2
- Outcome
- Mean sensor glucose (SG) level
Main finding
As reported in the abstract
Mean SG
P = 0.024
Observational data: associations, not effects.
Further findings
| Outcome | Day 4 | Day 2 |
|---|---|---|
| TARMedian | 27.6% (IQR 17.7%–44.9%) | 22.0% (IQR 7.3%–35.8%) |
| TIR | 66.5% (IQR 52.0%–79.8%) | 74.2% (IQR 59.9%–87.1%) |
| Time in tight range (TITR) | 42.2% (IQR 34.6%–54.1%) | 47.6% (IQR 37.1%–67.5%) |
Time above range (TAR)
- TAR worsened (increased) on day 4 vs day 2
Time in range (TIR)
- TIR worsened (decreased) on day 4 vs day 2
Time in tight range (TITR)
- TITR worsened (decreased) on day 4 vs day 2
Original publication
Observational Study of the Impact of Infusion Set Replacement in Insulin Pump Users on Glycemic Management. J Diabetes Sci Technol. Published 28 June 2025. doi:10.
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