Novel data-driven pathophysiological phenotypes among women with prediabetes in an Indian population
Authors' conclusion
CIRDP and HBPMIDP had higher progression rates to diabetes at one year compared to SIDP. Eighty percent of the pathophysiological prediabetes phenotypes displayed beta-cell dysfunction.
Study context
- Population
- Women with prediabetes in an Indian population; survey samplesurvey sample
- Participants
- 1,455 women
- Exposure
- Data-driven prediabetes phenotypes vs SIDP
- CIRDPn = 323
- SIROPn = 290
- SIDPn = 544reference
- HBPMIDPn = 298
- Outcome
- Progression to DM
- Follow-up
- One year
Methodological detailsk-means clustering, survey sample, 1-year follow-up
- K-means clustering
- Survey sample
- 1-year follow-up
Main finding
As reported in the abstract
Each group vs SIDPOdds ratio (95 % CI)
CIRDP
6.07(3.59–10.65)
HBPMIDP
2.05(1.10–3.87)
Observational data: associations, not effects.
Further findings
Phenotype distribution
Original publication
Novel data-driven pathophysiological phenotypes among women with prediabetes in an Indian population. Diabetes Res Clin Pract. Published 14 July 2025. doi:10.
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