Nonlinear association between hemoglobin glycation index and mortality in ischemic stroke Patients: Insights from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database
Authors' conclusion
Lower HGI is consistently related to poorer outcomes in patients with critical ischemic stroke. Higher HGI could be a protective factor in the short term but might increase mortality risk in the long term. WBC counts significantly mediate the association.
Study context
- Population
- Patients with critical ischemic stroke, MIMIC-IV database
- Participants
- 2,332 patients
- Exposure
- Hemoglobin glycation index (HGI) groups
- Outcome
- In-hospital mortality across HGI groups
Methodological detailsMIMIC-IV database, restricted cubic splines, mediation analysis
- MIMIC-IV database
- Restricted cubic splines
- Mediation analysis
Main finding
As reported in the abstract
- In-hospital mortality differed significantly across HGI groups
- P < 0.001
Observational data: associations, not effects.
Further findings
Nonlinear association of HGI with mortality
- L-shaped association with short-term (30-day and in-hospital) mortality
- Reverse J-shaped association with long-term (365-day) mortality
Mediation by white blood cell (WBC) counts
- WBC counts mediated the association; proportions mediated (%)
- 33.73, 19.65, and 30.00
Original publication
Nonlinear association between hemoglobin glycation index and mortality in ischemic stroke Patients: Insights from the MIMIC-IV database. Diabetes Res Clin Pract. Published 15 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →