Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity
Authors' conclusion
Our proteomics study suggests that cardiometabolic health (represented by MHO/MUO or individual MS markers) is associated with the concentration in plasma of several proteins involved in brain health. Larger-scale studies are needed to contrast/confirm these findings, with CD38 standing out as a particularly noteworthy and robust discovery.
Study context
- Population
- Caucasian children with overweight/obesity (39% girls), aged 10.1 ± 1.1 years, ActiveBrains project
- Participants
- 84 children
- Exposure
- Metabolically healthy obesity vs metabolically unhealthy obesity
- Outcome
- Neurological-related plasma proteins, MHO vs MUO
Main finding
As reported in the abstract
- Distinct concentrations of CD38, LAIR2, MANF and NRP2 proteins in metabolically healthy obesity (MHO) compared with metabolically unhealthy obesity (MUO)
Observational data: associations, not effects.
Original publication
Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity. Pediatr Obes. Published 29 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →