Neural correlates of inhibitory control in severe class III compared with class I/II obesity using a sample of endometrial cancer survivors seeking weight loss
Authors' conclusion
These results provide novel insights into inhibitory control and corresponding neural correlates in severe versus less severe classes of obesity and highlight the importance of targeting inhibitory control processes in weight-loss interventions, particularly for people with severe obesity and greater impulsivity.
Study context
- Population
- Stage I endometrial cancer survivors with obesity seeking weight loss in a lifestyle intervention, at baseline
- Participants
- 48 survivors
- Exposure
- Class III vs class I/II obesity
- Class IIIn = 27
- Class I/IIn = 21reference
- Outcome
- Inhibitory control (stop signal reaction time) and neural correlates of response inhibition by obesity class
- Follow-up
- Baseline
Methodological detailsbaseline data of a lifestyle intervention, functional MRI, stop signal task
- Baseline data of a lifestyle intervention
- Functional MRI
- Stop signal task
Main finding
As reported in the abstract
Stop signal reaction time
P < 0.01
Observational data: associations, not effects.
Further findings
fMRI activation, incorrect vs correct inhibition contrast
- Increased activation in thalamus and superior frontal gyrus in Class III but not Class I/II (whole brain cluster corrected)
- P < 0.05
Original publication
Neural correlates of inhibitory control in severe class III compared with class I/II obesity using a sample of endometrial cancer survivors seeking weight loss. Obesity (Silver Spring). Published 8 May 2023. doi:10.
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