National and regional burden of early-onset type 2 diabetes mellitus in the Americas from 1990 to 2023, attributable to modifiable risk factors, and projections to 2050: a systematic analysis for the global burden of disease study 2023
Authors' conclusion
Between 1990 and 2023, the burden of early-onset T2DM attributable to MRFs varied widely across the Americas, and, although health inequality improved in some regions, the overall burden is projected to increase through 2050.
Study context
- Population
- People aged 25–39 years with early-onset T2D attributable to modifiable risk factors, the Americas, 1990–2023
- Outcome
- Burden (mortality and DALYs) of early-onset T2D attributable to modifiable risk factors
- Follow-up
- 1990–2023
Methodological detailsJoinpoint regression, slope and concentration indices, Bayesian age-period-cohort projections
- Joinpoint regression
- Slope and concentration indices
- Bayesian age-period-cohort projections
Main finding
As reported in the abstract
- In 2023, highest age-standardized rates in Central Latin America; lowest in high-income regions
- Age-standardized DALY rate trended upward 1990–2023 in Andean Latin America and High-income North America
- Slight concentration of burden towards lower socioeconomic groups
- Males consistently bore a higher burden than females across all regions
Observational data: associations, not effects.
Further findings
Projections of absolute deaths and disability-adjusted life years (DALYs) · through 2050
- Continued rise in absolute deaths and DALYs forecast through 2050
Original publication
National and regional burden of early-onset type 2 diabetes mellitus in the Americas from 1990 to 2023, attributable to modifiable risk factors, and projections to 2050: a systematic analysis for the global burden of disease study 2023. Diabetes Res Clin Pract. Published 24 November 2025. doi:10.
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