Nailfold Capillary Changes in Primary Hyperparathyroidism
Authors' conclusion
Microvascular alterations in nailfold capillaries were observed in patients with PHPT. These findings suggest that, in addition to the previously reported cardiovascular involvement, PHPT may also affect peripheral microcirculation at the capillary level.
Study context
- Population
- Patients with PHPT and matched healthy controls; nailfold capillary morphology assessed by digital dermatoscopy
- Participants
- 62 vs 34
- Exposure
- PHPT vs matched healthy controls
- PHPTn = 62
- Healthy controlsn = 34reference
- Outcome
- Morphological changes in nailfold capillaries
Main finding
As reported in the abstract
Minor morphological changes (MiMC) in nailfold capillaries
- PHPT vs Healthy controls: P = 0.001
- PHPT vs Healthy controls: P < 0.001
Observational data: associations, not effects.
Further findings
Correlations of avascular area scores (AAS)
- AAS vs plasma parathormone (PTH)
- r = 0.498, p < 0.001
- AAS vs serum calcium
- r = 0.552, p < 0.001
- AAS vs age
- r = 0.346, p = 0.001
Independent associations
- Serum calcium independently associated with minor morphological changes (MiMC) scores
- P = 0.036
- Plasma PTH independently influenced AAS
- P = 0.032
- Age independently influenced AAS
- P = 0.002
Original publication
Nailfold Capillary Changes in Primary Hyperparathyroidism. Clin Endocrinol (Oxf). Published 1 March 2026. doi:10.
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