Myocardial mechano‐energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity
Authors' conclusion
Increased BMI is not an obligate determinant for reduced myocardial MEEi. Other known components of metabolic syndrome rather than increased BMI contributed to reduced myocardial MEEi.
Study context
- Population
- Nondiabetic individuals in the CATAnzaro MEtabolic RIsk factors (CATAMERI) studynondiabetic
- Participants
- 2,190 individuals
- Exposure
- Metabolically healthy vs unhealthy individuals across BMI categories
- Outcome
- Myocardial mechano-energetic efficiency (MEE) per gram of left ventricular mass (MEEi) by echocardiography
Main finding
As reported in the abstract
Myocardial MEEi, adjusted for age and sex
- No differences in MEEi among metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW) and metabolically healthy obesity (MHO)
- MEEi comparable among metabolically unhealthy normal weight (MUNW), metabolically unhealthy overweight (MUOW) and MUO
- MHNW, MHOW and MHO had significantly higher MEEi than their unhealthy counterparts
- Between MHNW and MHOW: P = 0.56
- Between MUNW and MUOW: P = 0.21
- Adjusted for age and sex
Observational data: associations, not effects.
Original publication
Myocardial mechano‐energetic efficiency is not impaired in patients with metabolically healthy overweight and obesity. Obesity (Silver Spring). Published 11 March 2024. doi:10.
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