Myocardial fat accumulation is associated with cardiac dysfunction in patients with type 2 diabetes, especially in elderly or female patients: a retrospective observational study
Authors' conclusion
Patients with type 2 diabetes, especially in elderly or female patients, who had more myocardial fat had more severe left ventricular systolic and diastolic dysfunctions. Reducing myocardial fat accumulation may be a therapeutic target for type 2 diabetes patients.
Study context
- Population
- T2D patients who underwent ECG-gated coronary computed tomography (CT) angiography and abdominal CT within 1 year, January 2000 to March 202172 males · 52 females
- Participants
- 124 patients
- Outcome
- Association of myocardial CT value (lower = more myocardial fat) with ejection fraction
Main finding
As reported in the abstract
Correlation of myocardial CT value with ejection fraction (EF)
r = 0.3644
p = 0.0004
Multiple regression: myocardial CT value independently associated with EF, estimate
0.304 (0.092 to 0.517); p = 0.0056 (95% CI)
Observational data: associations, not effects.
Further findings
Correlation of myocardial CT value with BMI, visceral fat area and subcutaneous fat area
- BMI
- r = - 0.1923
- Visceral fat area
- r = - 0.2654
- Subcutaneous fat area
- r = −0.3569
- Significance (all)
- P < 0.05
Subgroups ≥65 years and female: correlation of myocardial CT value with EF
- ≥65 years
- r = 0.3542
- Female
- r = 0.4085
- Significance (both)
- P < 0.01
Subgroups ≥65 years and female: correlation of myocardial CT value with early lateral annular tissue Doppler velocity (Lat e')
- ≥65 years
- r = 0.5148
- Female
- r = 0.5361
- Significance (both)
- P < 0.05
Subgroups ≥65 years and female: multiple regression
- Myocardial CT value independently associated with EF and Lat e'
- P < 0.05
Cohort characteristics
- Mean age
- 66.6 years
- Mean BMI
- 26.2 kg/m²
- Mean EF
- 67.6%
- Mean myocardial CT value
- 47.7 Hounsfield unit
Original publication
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