Musculoskeletal characteristics in older adults with overweight or obesity: Incorporating Nutrition, Vests, Education, and Strength Training (INVEST) in Bone Health trial baseline analysis
Authors' conclusion
Machine learning-derived CT metrics correlated strongly with DXA and muscle strength, with higher BMI linked to greater IMAT and poorer muscle quality.
Study context
- Population
- Older adults living with overweight or obesity; mean age 66 (SD 5) years, 75% female, mean BMI 33.6 (SD 3.3) kg/m²
- Participants
- 150 adults
Methodological detailslinear regression and mixed-effects models, factor analysis of radiomics data
- Linear regression and mixed-effects models
- Factor analysis of radiomics data
Primary result
As reported in the abstract
baseline
- DXA and computed tomography (CT)-derived muscle and IMAT measures higher in males than females
- all p < 0.01
- Midthigh muscle size significantly related to grip and knee extensor strength
- both p < 0.01
Original publication
Musculoskeletal characteristics in older adults with overweight or obesity: INVEST in Bone Health trial baseline analysis. Obesity (Silver Spring). Published 6 March 2025. doi:10.
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