Multiomics of Human Obesity and Related Multisystem Diseases
Authors' conclusion
Our analyses revealed key regulatory mechanisms influenced by and influencing obesity, offering valuable targets for biomarkers and clinical interventions.
Study context
- Population
- Individuals from the Cameron County Hispanic Cohort, with validation in ∼45,000 UK Biobank participantsvalidation ∼45,000 UK Biobank
- Participants
- 259 individuals
- Outcome
- Association of obesity-related traits with 2912 plasma proteins
Methodological detailsproteomic association study, colocalization, Mendelian randomization, external validation in UK Biobank
- Proteomic association study
- Colocalization
- Mendelian randomization
- External validation in UK Biobank
Main finding
As reported in the abstract
Plasma proteins associated with obesity metrics
Proteins significantly associated with obesity metrics (false discovery rate < 0.05)
122
Replicated in UK Biobank
121
Replicated proteins with evidence of statistical causality for obesity or obesity-associated illnesses
80 of 121
Original publication
Multiomics of Human Obesity and Related Multisystem Diseases. J Clin Endocrinol Metab. Published 24 June 2025. doi:10.
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