Lipids & metabolic liver disease
Multi-omics uncovers the pleiotropic genetic mechanisms linking MASLD and cardiometabolic syndromes
Authors' conclusion
This study provides a comprehensive map of the shared genetic architecture between MASLD and CKM syndrome, reveals novel causal genes and repurposable drug targets, and offers insights into precision medicine approaches for cardiometabolic and liver diseases.
Study context
- Population
- GWAS summary statistics for MASLD and 38 cardiovascular-kidney-metabolic (CKM) traits
- Outcome
- Shared genetic architecture of MASLD and CKM traits
Methodological detailsGWAS summary statistics, genetic correlation, causal inference, druggability evaluation
- GWAS summary statistics
- Genetic correlation
- Causal inference
- Druggability evaluation
Main finding
As reported in the abstract
- CKM traits with significant genetic correlation with MASLD, especially metabolic and cardiovascular conditions
- 16
- Pleiotropic loci
- 116
- Shared causal variants (e.g. rs429358 near APOE, influencing multiple traits)
- 65
- Unique candidate pleiotropic genes, enriched in lipid and cholesterol metabolism, highly expressed in liver, adipose and immune-related cell types (macrophages, endothelial cells)
- 152
- Genes validated by eQTL and pQTL data from multiple tissues and cohorts
- 131
Original publication
Multi-omics uncovers the pleiotropic genetic mechanisms linking MASLD and cardiometabolic syndromes. Cardiovasc Diabetol. Published 9 May 2026. doi:10.
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