Mortality risk for kidney transplant candidates with diabetes: a population cohort study
Main finding · All-cause mortalityResult — go to the resultRelative risk 0.26 95% CI 0.25–0.27Authors' conclusion
Kidney transplant candidates with diabetes have a lower chance of transplantation despite better survival after kidney transplantation vs remaining on dialysis. The reasons for this require further investigation to ensure equal transplantation opportunities.
Study context
- Population
- Wait-listed people with kidney failure receiving dialysis in the UK, listed for first kidney-alone transplant 2000–2019; 6594 (13.8%) with diabetes as cause of kidney failure6,594 with diabetes
- Participants
- 47,917 people
- Exposure
- Kidney transplant vs remaining on dialysis, in wait-listed candidates with and without diabetes
- Outcome
- All-cause mortality (time-to-death from listing)
Methodological detailsprospectively collected national registry data, adjusted non-proportional hazard Cox regression, transplantation as time-dependent covariate
- Prospectively collected national registry data
- Adjusted non-proportional hazard Cox regression
- Transplantation as time-dependent covariate
Main finding
All-cause mortality
Relative risk
0.26
95% CI 0.25–0.27
P < 0.001
Transplantvs Dialysis
RR 0.26 (95% CI 0.25–0.27); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Dialysis | P value |
|---|---|---|
| Proportion with diabetes as cause of kidney failure, by transplantationDialysis vs Transplant | 27.6% | P < 0.001 |
- Proportion with diabetes as cause of kidney failure, by transplantation: Transplant 8.4%
Characteristics of candidates with diabetes
- Candidates with diabetes more likely older, male and of ethnic minority background vs those without diabetes
Original publication
Mortality risk for kidney transplant candidates with diabetes: a population cohort study. Diabetologia. Published 6 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →