Mortality in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)
Authors' conclusion
Among people with diabetes of relatively short duration, cause of death was varied. Attention to health risks beyond cardiovascular diseases is warranted.
Study context
- Population
- People with T2D diagnosed within 10 years and no recent history of cardiovascular events or cancer
- Primary endpoint
- Overall mortality rate and major causes of death
- Follow-up
- Average of 5 years
Methodological detailscomparative effectiveness study, central adjudication of cause of death masked to treatment assignment, Cause of death adjudicated centrally by a committee masked to treatment assignment
- Comparative effectiveness study
- Central adjudication of cause of death masked to treatment assignment
- Cause of death adjudicated centrally by a committee masked to treatment assignment
Primary result
As reported in the abstract
Mortality rate
Mortality rate
0.59 per 100 participant-years
Underlying cause of death: cardiovascular-cause (composite)
38.6%
Underlying cause of death: cancer
26.8%
Further findings
Characteristics of participants who died
- Those who died were likely to be older, male, with a history of hypertension, a history of smoking, and moderate albuminuria
Original publication
Mortality in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). Diabetes Care. Published 22 January 2024. doi:10.
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