Modulation of Functional Activity of INS-VNTR Class I Haplotype Derived from Patients With Type 1 Diabetes
Authors' conclusion
Longer TRUs of the class I INS-VNTR haplotype favors INS expression in thymus and tolerance induction. Vitamin A supplementation could be beneficial for prevention of insulin autoimmunity at the early stages of T1D onset.
Study context
- Population
- Gender-, age- and human leukocyte antigen (HLA)-matched patients with T1D; INS-VNTR class I haplotypes subcloned into pGL3-luciferase vectormatched
- Participants
- 28 participants
- Comparison
- IAA− vs IAA+ patients with T1D
- Outcome
- Mean TRUs (average from both alleles)
Methodological detailsgender-, age- and HLA-matched
- Gender-, age- and HLA-matched
Main finding
As reported in the abstract
IAA-
39.8
mean
IAA+
35.2
mean
Original publication
Modulation of Functional Activity of INS-VNTR Class I Haplotype Derived from Patients With Type 1 Diabetes. J Clin Endocrinol Metab. Published 15 April 2025. doi:10.
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