Mitochondrial DNA copy number in adults with and without Type 1 diabetes
Authors' conclusion
mtDNA-cn is lower in T1D vs. CON, and in T1D kidney disease. In T1D, mtDNA-cn correlates inversely with age and inflammation, and positively with HDL-C, detectable C-peptide and pump use. Further clinical and basic science studies are merited.
Study context
- Population
- Adults with and without T1D
- Participants
- 178 vs 132
- Exposure
- T1D vs non-diabetic controls
- T1Dn = 178
- CONn = 132reference
- Outcome
- Whole blood mtDNA-cn (qPCR) and its associations with complications, inflammation and C-peptide
Main finding
As reported in the abstract
mtDNA-cn, median (LQ, UQ)
T1D
271
median · LQ, UQ 189–348
CON
320
median · LQ, UQ 264–410
P < 0.0001
Observational data: associations, not effects.
Further findings
T1D with kidney disease vs T1D without kidney disease
Median
| Outcome | T1D with kidney disease | T1D without kidney disease | P value |
|---|---|---|---|
| mtDNA-cn, T1D with vs without kidney diseaseLower with kidney disease | 238 (LQ, UQ 180–309) | 294 (LQ, UQ 198–364) | P = 0.02 |
Insulin injection vs Pump
Median
| Outcome | Insulin injection | Pump | P value |
|---|---|---|---|
| mtDNA-cn, insulin injection vs pump usersLower with insulin injection | 251 (LQ, UQ 180–340) | 322 (LQ, UQ 263–406) | P = 0.008 |
Detectable C-peptide in T1D across Mitochondrial DNA copy number (mtDNA-cn) tertiles
- Detectable C-peptide in T1D, lowest to highest mtDNA-cn tertiles
- 54%, 69%, 79%, p = 0.02
Univariate correlates of mtDNA-cn
- T1D: positive HDL-C; negative fasting glucose, white cell count (WCC), sVCAM-1, sICAM-1
- CON: negative WHR
Independent determinants of mtDNA-cn
- T1D: positive HDL-C; negative age, sICAM-1; AUROC
- 0.71
- CON: WCC negative, never smoking; positive female, pulse pressure; AUROC
- 0.74
Original publication
Mitochondrial DNA copy number in adults with and without Type 1 diabetes. Diabetes Res Clin Pract. Published 12 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →