Mild Variations in Thyroid Hormone Serum Concentrations Show Associations with the ET 6-6-R Developmental Test: Results from a Population-Based Pediatric Cohort in Germany
Authors' conclusion
The differential results for the developmental tests indicate that the associations are highly specific for particular aspects of development and even developmental stages. Therefore, single measurements have very limited explanatory power. </p>.
Study context
- Population
- Healthy children in a population-based pediatric cohort in Germany
- Outcome
- Associations between TSH, FT3 and FT4 and developmental test results (BSID III and ET 6-6-R)
Methodological detailspediatric, regression models, 946 children completed BSID III; 1,467 children completed ET 6-6-R
- Pediatric
- Regression models
- 946 children completed BSID III; 1,467 children completed ET 6-6-R
Main finding
As reported in the abstract
Higher TSH-SDS associated with lower ET 6-6-R scores in cognitive development, language development, fine and gross motor skills (all ps < 0.05)
β = −0.13 to β = −0.23
FT3 positively associated with gross motor skills (ps < 0.05)
β = 0.17
FT3 positively associated with fine motor skills (ps < 0.05)
β = 0.26
FT3 positively associated with cognition (ps < 0.05)
β = 0.15
Observational data: associations, not effects.
Original publication
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