Metformin Use and Risk of Delirium in Older Adults With Type 2 Diabetes
Main finding · DeliriumResult — go to the resultAdjusted hazard ratio 0.77 to 0.81Authors' conclusion
Metformin use is associated with a reduced risk of delirium in older adults with T2D, with higher doses offering greater protection.
Study context
- Population
- Older adults with T2Dmatched by propensity score
- Participants
- 66,568 vs 66,568
- Exposure
- Metformin users vs nonusers
- Metformin usersn = 66,568
- Nonusersn = 66,568reference
- Outcome
- Delirium
Methodological detailscompeting risk analysis of death
- Competing risk analysis of death
Main finding
As reported in the abstract
Adjusted hazard ratio
0.77 to 0.81
Observational data: associations, not effects.
Further findings
Delirium by cumulative and daily metformin dose
- Dose-response: higher cumulative and daily doses associated with greater reductions in delirium risk
Original publication
Metformin Use and Risk of Delirium in Older Adults With Type 2 Diabetes. Diabetes Care. Published 3 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →