Metabolically healthy obesity in adults with X-linked hypophosphatemia
Authors' conclusion
The prevalence of overweight and obesity is high among XLH patients and is associated with excess fat mass. However, the prevalence of glucose homeostasis abnormalities is not increased in patients compared to healthy controls, suggesting that metabolically healthy overweight or obesity predominates.
Study context
- Population
- Adults with X-linked hypophosphatemia (XLH) at a single tertiary referral center; 75% female, 97% PHEX mutation
- Participants
- 113 evaluated patients
- Exposure
- Adults with XLH vs age-, sex- and BMI-matched healthy controls
- Outcome
- Proportion of patients with BMI >25 kg/m²
Methodological detailssingle-centre, tertiary referral center, matched healthy controls subgroup
- Single-centre
- Tertiary referral center
- Matched healthy controls subgroup
Main finding
As reported in the abstract
Overweight or obesity (BMI >25 kg/m²)
Patients overweight or obese
63
56%
Median BMI
25.3 [IQR, 22.7; 29.2] kg/m²
Observational data: associations, not effects.
Secondary outcomes
FM% and adipose tissue surfaces
- BMI correlated with FM%, abdominal and thigh subcutaneous and intra-abdominal adipose tissue surfaces
Impaired fasting glucose, impaired glucose tolerance and diabetes (OGTT subgroup)
- Prevalence not different between XLH patients and matched controls
- Subgroup of patients vs age-, sex-, BMI-matched healthy controls
Original publication
Metabolically healthy obesity in adults with X-linked hypophosphatemia. Eur J Endocrinol. Published 9 August 2024. doi:10.
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