Metabolic traits affecting the relationship between liver fat and intrapancreatic fat: a mediation analysis
Authors' conclusion
At least one-quarter of the association between liver fat and IPFD is mediated by specific blood biomarkers (triacylglycerol, HDL-cholesterol and glucose), after accounting for potential confounding by age, sex, ethnicity and BMI. This unveils the complexity of the association between the two fat depots and presents specific targets for intervention.
Study context
- Population
- Individuals with MRI-measured liver fat and intrapancreatic fat deposition (IPFD); 16 blood metabolic traits measured
- Participants
- 353 individuals
- Outcome
- Proportion of the association between liver fat and IPFD mediated by metabolic traits
Methodological detailsMRI/magnetic resonance spectroscopy on the same 3.0 T scanner, adjusted for age, sex, ethnicity and BMI, bias-corrected bootstrap CIs with 5000 repetitions, IPFD quantified manually by two independent raters in duplicate
- MRI/magnetic resonance spectroscopy on the same 3.0 T scanner
- Adjusted for age, sex, ethnicity and BMI
- Bias-corrected bootstrap CIs with 5000 repetitions
- IPFD quantified manually by two independent raters in duplicate
Main finding
As reported in the abstract
Mediation of liver fat–IPFD association
Mediated by plasma glucose
6.8%
Mediated by HDL-C
17.9%
Mediated by triacylglycerol
24.3%
Original publication
Metabolic traits affecting the relationship between liver fat and intrapancreatic fat: a mediation analysis. Diabetologia. Published 4 October 2022. doi:10.
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