Metabolic syndrome parameters' variability and stroke incidence in hypertensive patients: evidence from a functional community cohort
Main finding · Total strokeResult — go to the resultHazard ratio 1.29 95% CI 1.09–1.52Authors' conclusion
Long-term fluctuations in metabolic syndrome parameters significantly increase the risk of total stroke, especially ischemic stroke. Maintaining low variability in metabolic syndrome parameters could benefit health, and hypertensive individuals must be regularly monitored.
Study context
- Population
- Individuals with hypertension from the Kailuan study; metabolic syndrome parameters (waist circumference (WC), fasting blood glucose (FBG), systolic blood pressure (SBP), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG)) collected in 2006, 2008 and 2010 surveys; variability assessed by coefficient of variation (CV)1,223 stroke cases
- Participants
- 17,789 individuals
- Exposure
- Number of high-variability metabolic syndrome parameters
- Outcome
- Total stroke
- Follow-up
- Median 9.32 years
Methodological detailscommunity-based (Kailuan study)
- Community-based (Kailuan study)
Main finding
As reported in the abstract
Hazard ratio
1.29
95% CI 1.09–1.52
≥ 3 vs 0
HR 1.29 (95% CI 1.09–1.52)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Ischemic stroke≥ 3 vs 0 | 1.31 (1.05–1.63) | |
| 0.512Hazard ratio (log scale) |
Total stroke by variability in SBP
- High vs low SBP variability, HR
- 1.24 (1.05-1.46) (95% CI)
Total stroke by variability in HDL-C
- High vs low HDL-C variability, HR
- 1.34 (1.09-1.64) (95% CI)
Original publication
Metabolic syndrome parameters' variability and stroke incidence in hypertensive patients: evidence from a functional community cohort. Cardiovasc Diabetol. Published 15 June 2024. doi:10.
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