Metabolic syndrome mediates the association between body roundness index and incident stroke risk in Chinese adults aged 45 years and older: Evidence from the CHARLS
Authors' conclusion
In metabolically healthy individuals, BRI shows a moderate predictive value for stroke, partly mediated by blood pressure.
Study context
- Population
- Participants of the CHARLS cohort, with and without metabolic syndrome (MetS)
- Exposure
- Body roundness index (BRI) and incident stroke, by MetS status; mediation by MetS components
- Outcome
- Incident stroke
Main finding
As reported in the abstract
Association of BRI with stroke by MetS status
Hazard ratio (95% CI)P value
Without MetS
2.50(1.69–3.67)
P < 0.001With MetS
0.97(0.43–2.18)
P < 0.935Observational data: associations, not effects.
Further findings
| Outcome | Without MetS | With MetS |
|---|---|---|
| Stroke discrimination (ROC) | ||
| AUC | 0.660 | 0.638 |
Stroke discrimination (ROC)
- BRI outperformed traditional indices in stroke discrimination
Mediation of BRI-stroke association
- Proportion explained by metabolic components
- about 22 %
- Proportion explained by blood pressure
- 11 %
- Other components not individually significant; mediation modest
Original publication
Metabolic syndrome mediates the association between body roundness index and incident stroke risk in Chinese adults aged 45 years and older: Evidence from the CHARLS. Diabetes Res Clin Pract. Published 10 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →