Metabolic syndrome, genetic susceptibility, and risk of chronic obstructive pulmonary disease: The UK Biobank Study
Main finding · Incident COPDResult — go to the resultHazard ratio 1.24 95% CI 1.17–1.32Authors' conclusion
Metabolic syndrome was found to be associated with an increased risk of COPD, regardless of genetic risk. It is crucial to conduct further randomized control trials to determine whether managing MetS and its individual components can potentially reduce the likelihood of developing COPD.
Study context
- Population
- Participants of the UK Biobank Study
- Participants
- 287,868 participants
- Exposure
- Metabolic syndrome (MetS) vs no MetS; high vs low genetic predisposition
- Outcome
- Incident COPD
Methodological detailsgenetic risk score from 277 SNPs, Cox proportional hazard models
- Genetic risk score from 277 SNPs
- Cox proportional hazard models
Main finding
As reported in the abstract
Hazard ratio
1.24
95% CI 1.17–1.32
MetSvs No MetS
HR 1.24 (95% CI 1.17–1.32)
- Incident chronic obstructive pulmonary disease (COPD) cases during 2 658 936 person-years of follow-up
- 5877
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| COPD, joint analysis: MetS and high genetic predispositionvs no MetS and low genetic predisposition | 1.50 (1.36–1.65) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
COPD by genetic predisposition (high vs low)
- High vs low genetic predisposition: increased risk of COPD
- 17%
Interaction between MetS and genetic risk
- No significant interaction between MetS and genetic risk
Original publication
Metabolic syndrome, genetic susceptibility, and risk of chronic obstructive pulmonary disease: The UK Biobank Study. Diabetes Obes Metab. Published 17 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →