Metabolic syndrome and epigenetic aging: a twin study
Authors' conclusion
The results of this study suggests that MetS is associated with accelerated epigenetic aging, independent of physical activity, smoking or alcohol consumption, and that the association may be explained by genetics.
Study context
- Population
- Twins and unrelated individuals aged 23–69 years; replication in unrelated individuals and twins from the same base populationdiscovery cohorts · replication in unrelated individuals 1,564 · twins 293
- Participants
- 268 twins
- Comparison
- Metabolic syndrome (MetS) vs no MetS
- MetSn = 56
- No MetSn = 212reference
- Outcome
- Epigenetic age acceleration from blood DNA methylation (GrimAge, DunedinPACE)
Methodological detailstwo independent discovery cohorts, two replication cohorts, within-twin-pair fixed-effects analyses
- Two independent discovery cohorts
- Two replication cohorts
- Within-twin-pair fixed-effects analyses
Main finding
As reported in the abstract
GrimAge age acceleration
MetS
2.078
mean · 95% CI 0.996,3.160 · years
No MetS
−0.549
mean · CI −1.053,–0.045 · years
Between-group p = 3.5E-5
Further findings
DunedinPACE · higher with MetS
P = 4.8E-11
Lifestyle adjustment and within-twin-pair analyses
- Adverse MetS component profile associated with accelerated aging; lifestyle adjustment attenuated associations, which remained significant for DunedinPACE
- Within-twin-pair analyses: genetics explains associations fully for GrimAge and partly for DunedinPACE
- Replication: association independent of lifestyle factors considered; genetics a significant confounder
Original publication
Metabolic syndrome and epigenetic aging: a twin study. Int J Obes (Lond). Published 25 January 2024. doi:10.
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