Metabolic profile‐based subgroups can identify differences in brain volumes and brain iron deposition
Authors' conclusion
Metabolic profiles were associated differentially with brain neuroimaging characteristics. Associations of BMR, BP and other individual biomarkers may provide insights into actionable mechanisms driving these brain associations.
Study context
- Population
- UK Biobank participants free from dementia and stroke
- Participants
- 26,239 participants
- Exposure
- Metabolic subgroups vs healthy reference subgroup; 39 individual biomarkers
- Outcome
- Brain MRI measures: total brain volume, grey matter volume (GMV), white matter volume, hippocampal volume (HV), white matter hyperintensity (WMH) volume, caudate iron deposition
Methodological detailsUK Biobank, self-organizing map (artificial neural network) metabolic subgroups
- UK Biobank
- Self-organizing map (artificial neural network) metabolic subgroups
Main finding
As reported in the abstract
Brain MRI measures by metabolic subgroup
- High TG and liver enzymes
- βstandardized (grey matter volume (GMV)) −0.20 (95% CI −0.24 to −0.16)
- High TG and liver enzymes
- βstandardized (hippocampal volume (HV)) −0.09 (95% CI −0.13 to −0.04)
- High TG and liver enzymes
- βstandardized (white matter hyperintensity (WMH) volume) 0.22 (95% CI 0.18–0.26)
- High TG and liver enzymes
- βstandardized (caudate iron deposition) 0.30 (95% CI 0.25–0.34)
Observational data: associations, not effects.
Further findings
Individual biomarkers: basal metabolic rate (BMR), per 1 SD increase
- BMR and caudate iron deposition, βstandardized (95% CI) per 1 SD increase
- 0.23 (0.22 to 0.24)
- BMR and GMV, βstandardized
- −0.15 (−0.16 to −0.14) (95% CI)
- BMR and HV, βstandardized
- −0.11 (−0.12 to −0.10) (95% CI)
Individual biomarkers: diastolic blood pressure (BP) and WMH volume
- Diastolic BP and WMH volume, βstandardized
- 0.13 (0.12 to 0.14) (95% CI)
Original publication
Metabolic profile‐based subgroups can identify differences in brain volumes and brain iron deposition. Diabetes Obes Metab. Published 21 September 2022. doi:10.
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