Risk of adverse events with liraglutide in heart failure with reduced ejection fraction: A post hoc analysis of the FIGHT trial
Primary result · Total HF hospitalizations or all-cause deathsResult — go to the resultIncidence rate ratio 1.41 95% CI 0.98–2.04Authors' conclusion
In patients with HFrEF, liraglutide might increase the risk of cardiovascular adverse effects, an effect possibly driven by excess risk of arrhythmias and worsening HF events. As this was a post hoc analysis, these results should be interpreted as exploratory and hypothesis-generating. Further RCTs must be conducted before drawing definitive conclusions.
Study context
- Population
- Recently hospitalized patients with heart failure with reduced ejection fraction (HFrEF), followed for 180 days
- Participants
- 300 participants
- Comparison
- Liraglutide vs placebo
- Primary endpoint
- Total events of HF hospitalizations or all-cause death
- Follow-up
- 180 days
Methodological detailsdouble-blind
- Double-blind
Primary result
Total HF hospitalizations or all-cause deaths
Incidence rate ratio
1.41
95% CI 0.98–2.04
P = 0.064
Events by treatment group
Placebo
96
events
Liraglutide
143
events
As reported in the abstract
Secondary outcomes
Events
| Outcome | Liraglutide | Placebo | IRR (95% CI) | P value | |
|---|---|---|---|---|---|
| Total arrhythmias | 39 | 21 | 1.76 (0.92–3.37) | P = 0.088 | |
| 0.20.5125Incidence rate ratio (log scale) |
Heart failure (HF) hospitalizations or all-cause deaths by New York Heart Association (NYHA) class (liraglutide vs placebo)
- NYHA Class III to IV, IRR
- 1.86 (1.21-2.85) (95% CI)
- NYHA Class I to II, IRR
- 0.62 (0.31-1.23) (95% CI)
- Interaction P
- interaction P = 0.008
HF hospitalizations or all-cause deaths by diabetes
- Risk with liraglutide higher among patients with diabetes
- interaction P = 0.051
Arrhythmic events by implanted cardiac device
- Risk higher among those without an implanted cardiac device
- interaction P = 0.047
Safety
| Outcome | IRR (95% CI) | P value | |
|---|---|---|---|
| Total prespecified events of interest | 1.43 (1.06–1.92) | P = 0.018 | |
| 0.512Incidence rate ratio (log scale) |
Original publication
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