Lipids & metabolic liver disease
Measures of comorbid cardiometabolic burden and cardiovascular disease risk in people with MRI-confirmed steatotic liver disease: a prospective cohort study
Authors' conclusion
CMRF burden is a key determinant of cardiovascular risk in people with SLD, but data-driven CMRF patterns do not improve risk prediction beyond simple counts.
Study context
- Population
- UK Biobank participants with MRI-confirmed liver steatosis (39% women)
- Participants
- 10,121 participants
- Exposure
- CMRF count and CMRF patterns vs cardiovascular disease (CVD) risk
- Outcome
- Incidence and mortality of CVD, and all-cause mortality, by CMRF count and patterns
- Follow-up
- Median 4.9 years
Methodological detailsUK Biobank, latent class analysis
- UK Biobank
- Latent class analysis
Main finding
As reported in the abstract
Risk per each additional CMRF
CVD, HR per each additional CMRF
1.23
1.08, 1.40
CVD mortality, HR per each additional CMRF
1.47
1.07, 2.02
All-cause mortality, HR per each additional CMRF
1.25
1.08, 1.44
Events recorded
268 CVD events and 212 deaths
Observational data: associations, not effects.
Further findings
Prevalence of ≥ 2 cardiometabolic risk factors (CMRFs)
- Steatotic liver disease (SLD) participants with ≥ 2 CMRFs
- ≈95%
CMRF patterns
- Three distinct CMRF patterns identified; certain high-burden patterns associated with increased CVD risk, substantially attenuated after adjusting for CMRF count
Original publication
Measures of comorbid cardiometabolic burden and cardiovascular disease risk in people with MRI-confirmed steatotic liver disease: a prospective cohort study. Cardiovasc Diabetol. Published 29 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →