Measured Resting Energy Expenditure by Indirect Calorimetry and Energy Intake in Long-Term Growth Hormone-Treated Children with PWS
Authors' conclusion
In children with PWS, mREE increases with age. GH-treatment duration is not associated, whereas LBM is an important determinant of mREE. Children with PWS have a low to very low energy intake compared to DER for age- and sex-matched children, with a declining intake when becoming older.
Study context
- Population
- Growth hormone (GH)-treated children with PWS (1.0 mg GH/m²/day); mean (SD) age 8.53 (4.35) years; median (IQR) GH-treatment duration 7 (4–11) years
- Participants
- 52 children
- Outcome
- mREE (indirect calorimetry), energy intake and body composition
Main finding
As reported in the abstract
- Mean energy intake lower vs daily energy requirements (DER) for age- and sex-matched healthy children
- p < 0.001
- Less intake vs DER, children aged 3.5-12 years
- 23 to 36%
- Less intake vs DER, children aged 12-18 years
- 49%
- Normal resting energy expenditure (REE) (vs predicted REE)
- Fifty percent
- Decreased REE
- 17.3%
- Elevated REE
- 32.7%
Observational data: associations, not effects.
Original publication
Measured Resting Energy Expenditure by Indirect Calorimetry and Energy Intake in Long-Term Growth Hormone-Treated Children with PWS. Horm Res Paediatr. Published 16 February 2024. doi:10.
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