MDRD is the estimated glomerular filtration rate (eGFR) equation most strongly associated with 4-year mortality among patients with diabetes in Colombia
Authors' conclusion
Compared with other eGFR equations, MDRD showed the strongest association with all-cause mortality in a sample of Latin-American patients with diabetes. This difference was most pronounced among patients of black race.
Study context
- Population
- Adults with diabetes assisted by the Colombian Health System, July 1, 2015–June 30, 2019; 58% female, 7.2% black race, mean age 62.3, HbA1c 7.4%
- Participants
- 758,219 adults
- Exposure
- eGFR by Cockcroft-Gault vs MDRD vs CKD-EPI vs CKD-EPI without race (CKD-EPI-NR) and 4-year all-cause mortality
- Outcome
- All-cause mortality
- Follow-up
- 4-year
Methodological detailsnationwide, centralized database
- Nationwide
- Centralized database
Main finding
As reported in the abstract
Discrimination of survival status (area under ROC curve) by eGFR equation
- AUC greatest for MDRD, followed by CKD-EPI-NR, CKD-EPI and Cockcroft-Gault, in that order
- p<0.001 for all differences
- Odds of death decreased per additional mL/min of eGFR (each equation, continuous)
- 1.1%-1.5%
Observational data: associations, not effects.
Further findings
Black race: adjusted OR of mortality, chronic kidney disease (CKD) stage 4 vs stage 1
| aOR (95% CI) | ||
|---|---|---|
| MDRDStage 4vs stage 1 | 4.63 (3.39–6.35) | |
| CKD-EPI-NRStage 4vs stage 1 | 3.66 (2.85–4.69) | |
| CKD-EPIStage 4vs stage 1 | 3.01 (2.38–3.81) | |
| Cockcroft-GaultStage 4vs stage 1 | 2.82 (2.29–3.49) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Deaths over follow-up
- Deaths
- 35,296
Original publication
MDRD is the eGFR equation most strongly associated with 4-year mortality among patients with diabetes in Colombia. BMJ Open Diabetes Res Care. Published 20 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →