Maternal–Neonatal Metabolic Continuity and Early Postnatal Hypothalamic-pituitary-gonadal (HPG) Axis Activity in Healthy Term Neonates
Authors' conclusion
Maternal metabolic markers were associated with neonatal metabolic parameters but were not strongly associated with early neonatal gonadotropin levels in this cohort.
Study context
- Population
- Healthy term neonates; maternal venous blood at delivery, neonatal blood within first 24 h after birth20 males
- Participants
- 40 neonates
- Outcome
- Associations of maternal metabolic markers with neonatal leptin and LH
- Follow-up
- Within first 24 h after birth
Methodological detailsFalse discovery rate (FDR) correction (Benjamini-Hochberg)
- FDR correction (Benjamini-Hochberg)
Main finding
As reported in the abstract
within first 24 h after birth
Maternal leptin vs neonatal leptin, r
r = 0.52
p = 0.001
Maternal leptin vs neonatal leptin, adjusted β
adjusted β = 0.47
p = 0.001
Maternal leptin vs neonatal LH, not significant
β = 0.00009
p = 0.347
Sex as strongest independent predictor of neonatal LH
β = 1.21
p = 0.011
Observational data: associations, not effects.
Further findings
Neonatal leptin and triceps skinfold thickness
- Neonatal leptin positively associated with triceps skinfold thickness
- β = 1503.14, p = 0.034
Exploratory associations
- Most exploratory associations not significant after FDR correction
Original publication
Maternal–Neonatal Metabolic Continuity and Early Postnatal HPG Axis Activity in Healthy Term Neonates. Clin Endocrinol (Oxf). Published 30 July 2026. doi:10.
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