Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children
Main finding · Developmental delay across the 5 domainsResult — go to the resultAdjusted odds ratio 0.464 95% CI 0.229–0.943Authors' conclusion
mFPG level in early gestation was not associated with an increased risk of any developmental delays in 2-year-old children.
Study context
- Population
- Mother-child pairs in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study; Maternal fasting plasma glucose (mFPG) measured before 24 gestational weeks
- Participants
- 1,541 mother-child pairs
- Exposure
- Maternal FPG level in early gestation
- Outcome
- Developmental delay in children (Ages and Stages Questionnaire, third edition, assessed by mothers)
- Follow-up
- 2 years old
Methodological detailsbirth cohort, multiple logistic regression
- Birth cohort
- Multiple logistic regression
Main finding
Developmental delay across the 5 domains
Adjusted odds ratio
0.464
95% CI 0.229–0.943
mFPG ≤70 mg/dLvs mFPG 71 to 94 mg/dL
aOR 0.464 (95% CI 0.229–0.943)
As reported in the abstract
- mFPG as a continuous variable, aOR (95% CI 0.990-1.018) for developmental delay across 5 domains; not associated
- 1.004
Observational data: associations, not effects.
Further findings
Prevalence of mFPG ≥95 mg/dL
- Prevalence of mFPG ≥95 mg/dL
- 5.2%
Prevalence of developmental delay · 2 years old
- Children with developmental delays
- 15.1%
Original publication
Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. J Clin Endocrinol Metab. Published 20 January 2025. doi:10.
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