Mapping the landscape of childhood obesity: genomic insights and socioeconomic status in Indian school‐going children
Authors' conclusion
Our study identified genetic variants associated with childhood OB and highlighted the gene-environmental interaction in childhood OB.
Study context
- Population
- Indian school-going children; childhood obesityGenome-wide association study (GWAS) N = 5673
- Outcome
- Genetic variants associated with childhood OB
Methodological detailstwo-staged GWAS, independent exome-wide association study (ExWAS), generalized linear model assuming additive effect, rare-variant burden testing
- Two-staged GWAS
- Independent ExWAS
- Generalized linear model assuming additive effect
- Rare-variant burden testing
Main finding
As reported in the abstract
Rare-variant testing highlighted genes
101
Further findings
Socioeconomic status (SES) as modifier of genetic susceptibility
- SES can modulate the inherent susceptibility to obesity (OB)
Original publication
Mapping the landscape of childhood obesity: genomic insights and socioeconomic status in Indian school‐going children. Obesity (Silver Spring). Published 25 February 2025. doi:10.
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