Mapping shared genetic determinants of estimated glomerular filtration rate (eGFR) and albuminuria with a focus on type 2 diabetes: a large-scale European study
Authors' conclusion
This study identifies several shared genetic loci underlying eGFR and UACR in both general and T2D European populations. These findings highlight common pathobiological pathways between albuminuria and reduced kidney function and provide a genetic map that may inform future CKD risk stratification and towards the development of therapeutic targets.
Study context
- Population
- UK Biobank participants of primarily European descent (94%), with a T2D subgroup; 423 SNPs previously associated with eGFR in a large GWAS meta-analysis
- Participants
- 432,451 vs 16,265
- Exposure
- Overall population vs T2D
- Overall populationn = 432,451
- T2Dn = 16,265
- Outcome
- Association of 423 eGFR-associated SNPs with (a) eGFR2021 (2021 race-free CKD-EPI creatinine equation) and (b) UACR
Methodological detailsobservational, genetic association analysis, Bonferroni correction, Multiple linear regression adjusted for systolic blood pressure, age, sex and first 10 genetic principal components
- Observational
- Genetic association analysis
- Bonferroni correction
- Multiple linear regression adjusted for systolic blood pressure, age, sex and first 10 genetic principal components
Main finding
As reported in the abstract
- Overall population: loci nominally associated with eGFR2021
- 422
- Overall population: of these, nominally associated with urine albumin-creatinine ratio (UACR) (p≤0.05)
- 75
- Overall population: significant after bonferroni correction (BC)
- 12
- T2D: loci nominally associated with eGFR2021
- 76
- T2D: also nominally associated with UACR (p≤0.05)
- 6
- T2D: significant after BC
- 1
Observational data: associations, not effects.
Further findings
- Two pleiotropic loci (GSTA2, USP2-AS1) suggested diabetes-specific effects
- 2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Mapping shared genetic determinants of eGFR and albuminuria with a focus on type 2 diabetes: a large-scale European study. BMJ Open Diabetes Res Care. Published 26 May 2026. doi:10.
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