Manual chart review reveals bisphosphonate exposure misclassification in atypical femur fracture patients: auditing medical records in two international cohorts
Authors' conclusion
Misclassification of BP exposure occurs and can substantially affect reported rates of BP-naïve AFF, but it does not fully explain the wide variation observed across studies.
Study context
- Population
- Patients with atypical femur fracture (AFF) in two population-based cohorts, Sweden and Kaiser Permanente Southern California
- Participants
- 172 vs 306
- Exposure
- Swedish AFF cohort vs Kaiser Permanente Southern California (KPSC) AFF cohort: Bisphosphonate (BP)-naïve proportion before and after manual record review
- Swedenn = 172
- KPSCn = 306
- Outcome
- Proportion of AFF patients without bisphosphonate (BP) exposure (BP-naïve) after manual review of medical and pharmacy records
Methodological detailspopulation-based, manual review of medical records and pharmacy data, two international cohorts
- Population-based
- Manual review of medical records and pharmacy data
- Two international cohorts
Main finding
As reported in the abstract
| Group | Value | Total | Proportion BP-naïve before review | Initially BP-naïve with evidence of prior BP use |
|---|---|---|---|---|
| Swedish | 22.1% | 172 | ||
| KPSC | 2.9% | 9.5 | 20 of 29 |
Value
Swedish22.1%
KPSC2.9%
Total
Swedish172
KPSC— not stated in the abstract
Proportion BP-naïve before review
Swedish— not stated in the abstract
KPSC9.5
Initially BP-naïve with evidence of prior BP use
Swedish— not stated in the abstract
KPSC20 of 29
Observational data: associations, not effects.
Original publication
Manual chart review reveals bisphosphonate exposure misclassification in atypical femur fracture patients: auditing medical records in two international cohorts. Osteoporos Int. Published 28 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →