MAFLD and glomerular hyperfiltration in subjects with prediabetes, visceral obesity and “preserved” kidney function: A cross-sectional study
Main finding · HyperfiltrationResult — go to the resultOdds ratio 3.36 95% CI 2.33–4.84Authors' conclusion
More than half of subjects with prediabetes, visceral obesity and eGFR ≥ 60 ml/min presented MAFLD that was associated with hyperfiltration and potentiated the age-related eGFR decline.
Study context
- Population
- Spanish civil servants aged 18–65 years with prediabetes (FPG ≥ 100 and ≤ 125 mg/dL, ADA), visceral obesity (waist ≥ 94 cm men, ≥ 80 cm women, IDF) and de-indexed estimated glomerular filtration rate (eGFR) ≥ 60 ml/min, occupational health visits
- Participants
- 6,697 participants
- Exposure
- MAFLD vs no MAFLD
- MAFLDn = 4,213
- Outcome
- Prevalence of MAFLD; association of MAFLD with hyperfiltration (eGFR > age- and sex-specific 95th percentile)
Main finding
Hyperfiltration
Odds ratio
3.36
95% CI 2.33–4.84
P < 0.001
MAFLDvs Non-MAFLD
OR 3.36 (95% CI 2.33–4.84); P < 0.001
As reported in the abstract
- MAFLD prevalence
- 4213 (62.9%)
- Hyperfiltering
- 330 (4.9%)
- MAFLD in hyperfiltering vs non-hyperfiltering subjects
- 86.4% vs 61.7%, P < 0.001
Observational data: associations, not effects.
Further findings
BMI, waist circumference, systolic, diastolic, mean arterial pressure and hypertension prevalence
- Higher in hyperfiltering than in non-hyperfiltering subjects
- P < 0.05
Age-related eGFR decline (stratified analyses)
- MAFLD potentiated age-related eGFR decline vs non-MAFLD
- P < 0.001
Original publication
MAFLD and glomerular hyperfiltration in subjects with prediabetes, visceral obesity and “preserved” kidney function: A cross-sectional study. Diabetes Res Clin Pract. Published 23 May 2023. doi:10.
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