Low Mitotic Activity in Papillary Thyroid Cancer: A Marker for Aggressive Features and Recurrence
Main finding · RecurrenceResult — go to the resultHazard ratio 2.96 95% CI 1.28–6.87Authors' conclusion
Low mitotic activity is relatively common in PTC and its behavior lies within a spectrum between no and high mitotic activity. Given its association with aggressive clinicopathologic features and recurrence, low mitotic activity should be considered when risk stratifying patients with PTC for recurrence.
Study context
- Population
- Consecutive patients with papillary thyroid cancer (PTC) at a single institution, 2018–2022
- Participants
- 640 PTCs
- Exposure
- Low vs no and high mitotic activity in PTC
- No mitotic activityn = 515reference
- Low mitotic activityn = 110
- High mitotic activityn = 15
- Outcome
- Recurrence
Methodological detailssingle-institution, consecutive series
- Single-institution
- Consecutive series
Main finding
As reported in the abstract
Hazard ratio
2.96
95% CI 1.28–6.87
P = 0.01
By group
Low mitotic activityvs No mitotic activity
HR 2.96 (95% CI 1.28–6.87); P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Intermediate- and high-risk ATA risk stratificationLow mitotic activity vs No mitotic activity · higher with low mitotic activity | P < 0.001 |
Clinicopathologic features (vascular invasion, gross extrathyroidal extension, lymph node metastases)
- Rates with low mitotic activity were in between those of no and high mitotic activity
Original publication
Low Mitotic Activity in Papillary Thyroid Cancer: A Marker for Aggressive Features and Recurrence. J Clin Endocrinol Metab. Published 30 March 2024. doi:10.
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