Low hemoglobin, even within the normal range, is associated with diabetic kidney disease
Main finding · Incident DKDResult — go to the resultHazard ratio 1.58 95 % CI 1.19–2.21Authors' conclusion
Lower Hb is associated with incident DKD, even in patients with normal Hb levels, independent of other risk factors.
Study context
- Population
- Patients with T2D without diabetic kidney disease (DKD) at baseline, six clinics affiliated with Lee's United Clinic, Taiwan; 93 (5.6 %) had anemia at baseline
- Participants
- 1,657 patients
- Exposure
- Lowest vs highest quartile of baseline hemoglobin (Hb)
- Outcome
- Incident DKD
- Follow-up
- Average 5.7 ± 2.6 years
Methodological detailsmulticentre (six clinics)
- Multicentre (six clinics)
Main finding
As reported in the abstract
Hazard ratio
1.58
95 % CI 1.19–2.21
P < 0.001
Q1vs Q4
HR 1.58 (95 % CI 1.19–2.21); P < 0.001
- Developed DKD (whole cohort)
- 594 patients (35.8 %)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | P value | |
|---|---|---|---|
| Incident DKD, subgroup with normal Hb (men ≥ 120 g/l, women ≥ 110 g/l): Q'1 (Hb ≤ 132 g/l)vs Q'4 (Hb ≥ 154 g/l) | 1.29 (1.08–1.72) | P = 0.042 | |
| 0.512Hazard ratio (log scale) |
Original publication
Low hemoglobin, even within the normal range, is associated with diabetic kidney disease. Diabetes Metab. Published 18 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →