Low-Carbohydrate Diet Scores and Mortality Among Adults With Incident Type 2 Diabetes
Authors' conclusion
Among people with T2D, greater adherence to LCD patterns that emphasize high-quality sources of macronutrients was significantly associated with lower total, cardiovascular, and cancer mortality.
Study context
- Population
- Participants with incident T2D in the Nurses' Health Study and Health Professionals Follow-up Study
- Participants
- 10,101 participants139,407 person-years
- Exposure
- Per 10-point increment of postdiagnosis low-carbohydrate diet scores
- Outcome
- Total mortality
Methodological detailsmultivariable-adjusted Cox models, pooled analysis of Nurses' Health Study and Health Professionals Follow-up Study
- Multivariable-adjusted Cox models
- Pooled analysis of Nurses' Health Study and Health Professionals Follow-up Study
Main finding
As reported in the abstract
Total mortality per 10-point increment of postdiagnosis LCDS
Hazard ratio (95% CI)
TLCDS
0.87(0.82–0.92)
VLCDS
0.76(0.71–0.82)
HLCDS
0.78(0.73–0.84)
Per 10-point increment, as printed
- Deaths
- 4,595
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) and cancer mortality
- CVD deaths
- 1,389
- Cancer deaths
- 881
- Both VLCDS and HLCDS associated with significantly lower CVD and cancer mortality
Total mortality per 10-point increase of LCDS from prediagnosis to postdiagnosis
- Total LCD score (TLCDS): lower total mortality
- 12% (7%, 17%)
- VLCDS: lower total mortality
- 25% (19%, 30%)
- HLCDS: lower total mortality
- 25% (19%, 30%)
Original publication
Low-Carbohydrate Diet Scores and Mortality Among Adults With Incident Type 2 Diabetes. Diabetes Care. Published 14 February 2023. doi:10.
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