Longitudinal Observation of Children with Achondroplasia: Findings from a Global Natural History Study (ACHieve)
Authors' conclusion
ACHieve was one of the largest longitudinal natural history studies of achondroplasia to date and included the largest prospective Chinese achondroplasia cohort. The results demonstrated common trajectories in growth parameters regardless of region, indicating the generalizability of findings.
Study context
- Population
- Children ≤8 years old with achondroplasia not receiving growth-promoting therapy, 15 countries (83 from China)
- Participants
- 259 children15 countries
- Outcome
- Growth velocity, body proportionality and clinical events
- Follow-up
- Median 21 months
Methodological detailsglobal, longitudinal, Evaluated every 6 months for anthropometric parameters and clinical events
- Global
- Longitudinal
- Evaluated every 6 months for anthropometric parameters and clinical events
Main finding
As reported in the abstract
- Mean annualized growth velocity, males, age 1
- 9.3 cm/year
- Mean annualized growth velocity, females, age 1
- 10.4 cm/year
- Mean annualized growth velocity, males, age 4
- 4.1 cm/year
- Mean annualized growth velocity, females, age 4
- 4.6 cm/year
- Participants with clinical events
- 77.2%
- Share of clinical events considered related to achondroplasia
- 34.0%
Observational data: associations, not effects.
Further findings
Median age of diagnosis
- China
- ≈52 weeks
- Elsewhere
- 2 weeks
Deaths
- Deaths (one accident, one cardiac arrest of unknown origin)
- 2
Original publication
Longitudinal Observation of Children with Achondroplasia: Findings from a Global Natural History Study (ACHieve). Horm Res Paediatr. Published 8 January 2026. doi:10.
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