Longitudinal Mediating Effect of Fat Mass and Lipids on Sedentary Time, Light PA, and Moderate-to-vigorous Physical Activity (MVPA) with Inflammation in Youth
Authors' conclusion
ST worsens inflammation, but increased LPA had a 2-fold inflammatory-lowering effect and was more resistant to the attenuating effect of fat mass compared with MVPA, and hence should be targeted in future interventions.
Study context
- Population
- Children from the Avon Longitudinal Study of Parents and Children, UK, with ≥2 accelerometer-based measures of sedentary time (ST), light physical activity (LPA) and MVPA at ages 11, 15 and 24 years and complete high-sensitivity C-reactive protein (hsCRP) at ages 15, 17 and 24 years; 58% female; mean (SD) baseline age 11.7 (0.2) years
- Participants
- 792 children
- Outcome
- Mediating role of fat mass, lipids and insulin resistance in associations of cumulative ST, LPA and MVPA with inflammation (hsCRP)
- Follow-up
- 13-year follow-up
Methodological detailslongitudinal, mediation analysis using structural equation models
- Longitudinal
- Mediation analysis using structural equation models
Main finding
As reported in the abstract
Insulin resistance partly suppressed the positive association of ST with hsCRP among participants with overweight/obesity
23.5% suppression
Fat mass partly mediated the negative association of LPA with hsCRP
30% mediation
Fat mass mediation effect on the negative association of MVPA with hsCRP
77%
Observational data: associations, not effects.
Further findings
Trajectories of movement behaviours and hsCRP · 13-year follow-up
- ST increased, LPA decreased, MVPA had a U-shaped increase, and hsCRP increased
Original publication
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