Longitudinal Height Growth in Children and Adolescents with Type-1 Diabetes Mellitus Compared to Controls in Pune, India
Authors' conclusion
The results show that the physiological response to T1DM is to grow more slowly, and to delay and extend the pubertal growth spurt. The effects are dose-related, with more severe disease associated with greater growth faltering.
Study context
- Population
- Indian children and adolescents aged 4–19 years with T1D and controls without diabetes, Pune
- Participants
- 460 vs 1,470
- Exposure
- Children with T1D vs controls without diabetes
- T1DMn = 460
- Controlsn = 1,470reference
- Outcome
- Height growth curves (mean size, pubertal timing and intensity) modelled with SITAR
Methodological detailsSuperImposition by Translation and Rotation (SITAR) mixed effects growth modelling, diabetes cohort compared with school-children control cohort
- SITAR mixed effects growth modelling
- Diabetes cohort compared with school-children control cohort
Main finding
As reported in the abstract
Variance in height explained by SITAR
99%
Children with diabetes shorter than controls (boys/girls)
4/5 cm
Pubertal growth spurt later in children with diabetes (boys/girls)
1/6 months
Pubertal growth spurt less intense in children with diabetes (boys/girls)
−5%/−10%
Observational data: associations, not effects.
Further findings
Mean HbA1c by age (SITAR) in T1DM · age 15 years
- Peak mean HbA1c
- 10.5%
- Higher than earlier in childhood by
- 1.0%
Determinants of individual growth patterns
- Mean height per +1 SD midparental height
- 3.4 cm more
- Mean height per +1 SD HbA1c, girls
- 2 cm less
- Growth patterns highly significantly related to parental height, age at diabetes diagnosis, diabetes duration and mean HbA1c
Original publication
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