Detectable C-Peptide and Diabetic Ketoacidosis Risk in Type 1 Diabetes
Primary result · DKAResult — go to the resultHazard ratio 0.07 95% CI 0.01–0.48Authors' conclusion
Endogenous insulin production was significantly associated with lower DKA risk
Study context
- Population
- Participants with T1D in the Diabetes Control and Complications Trial; 53% male, median age 27 years
- Participants
- 1,441 participants
- Comparison
- Detectable stimulated C-peptide vs C-peptide ≤0.2 nmol/L
- Primary endpoint
- DKA incidence (recurrent DKA events)
- Follow-up
- average 6.5-year follow-up
Methodological detailspublicly available data repository, Andersen-Gill models for recurrent events, time-dependent covariates, crude and adjusted models
- Publicly available data repository
- Andersen-Gill models for recurrent events
- Time-dependent covariates
- Crude and adjusted models
Primary result
DKA
Hazard ratio
0.07
95% CI 0.01–0.48
P = 0.007
Events by treatment group
C-peptide >0.2 nmol/L
1
events
C-peptide ≤0.2 nmol/L
99.44%
179 events
C-peptide >0.2 nmol/Lvs C-peptide ≤0.2 nmol/L
HR 0.07 (95% CI 0.01–0.48); P = 0.007
As reported in the abstract
- Participants with diabetic ketoacidosis (DKA)
- 129 (9%), 180 events
Original publication
Detectable C-Peptide and Diabetic Ketoacidosis Risk in Type 1 Diabetes. Diabetes Care. Published 9 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →