Longitudinal comparison of bone, growth, and biochemical markers in breastfed HIV-exposed uninfected and HIV-unexposed Ugandan children
Authors' conclusion
These findings suggest early onset growth deficits and altered bone metabolism in CHEU by 3 mo of age, possibly linked to the TDF-containing ART initiated during pregnancy and/or disruptions in bone metabolism observed in their mothers.
Study context
- Population
- Breastfed Ugandan children followed to age 18 mo
- Participants
- 85 vs 80
- Exposure
- Children HIV-exposed uninfected (CHEU) vs CHUU
- CHEUn = 85
- CHUUn = 80reference
- Outcome
- Growth, bone mineral accretion and biochemical markers of growth and bone metabolism
- Follow-up
- To age 18 mo
Methodological detailsanalysis of data from the Gumba study
- Analysis of data from the Gumba study
Main finding
As reported in the abstract
CHEU had slower growth by WK14 and lower body weight and fat mass by WK26
≈0.5 kg
Observational data: associations, not effects.
Further findings
Stunting · WK78
| Outcome | Group difference (%) (95% CI) | P value |
|---|---|---|
| CTX (bone resorption marker) · WK14Coinciding with higher maternal CTX | +50.9 (24.1) | P < 0.001 |
| CTX (bone resorption marker) · WK78 | +45.6 (28.9) | P < 0.05 |
- Whole-body BMC and bone area · WK14 and WK26 · lower in CHEU
- P = 0.03 and .0003 for interaction
Whole-body BMC and bone area · WK14 and WK26
- Similar whole-body areal BMD before and after size adjustment
Biochemical markers of growth or bone formation
- No group differences
Original publication
Longitudinal comparison of bone, growth, and biochemical markers in breastfed HIV-exposed uninfected and HIV-unexposed Ugandan children. J Bone Miner Res. Published 3 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →