Longitudinal Change in Serum Neurofilament Light Chain in Type 2 Diabetes and Early Diabetic Polyneuropathy: ADDITION-Denmark
Authors' conclusion
Our findings suggest that preceding s-NfL trajectories differ slightly between those with and without DPN and imply a possible biomarker value of s-NfL trajectories in DPN.
Study context
- Population
- People with screen-detected T2D, ADDITION-Denmark cohort; biobank samples from 5- and 10-year follow-ups
- Participants
- 178 people
- Comparison
- T2D with DPN vs without DPN
- +DPNn = 39
- -DPNn = 139reference
- Outcome
- Longitudinal change in serum NfL (s-NfL) and NfL z-scores
- Follow-up
- 5- to 10-year follow-up
Methodological detailssecondary analysis of the ADDITION-Denmark cohort
- Secondary analysis of the ADDITION-Denmark cohort
Main finding
As reported in the abstract
Longitudinal s-NfL change
+DPN vs -DPNHigher s-NfL increase, % (95% CI)
Longitudinal s-NfL change
17.4(4.3–32.2)
- Greater in +DPN
- higher NfL z-score increase 0.31 SD (95% CI 0.03–0.60)
Observational data: associations, not effects.
Further findings
Serum NfL (s-NfL) at 5-year follow-up and nerve conduction studies at 10-year follow-up
- Positively associated with nerve conduction studies, but not with DPN risk
- P = 0.02 to <0.001
AUCs of s-NfL vs Michigan Neuropathy Screening Instrument score or vibration detection thresholds
- AUCs for s-NfL not inferior to AUCs for MNSI questionnaire score or vibration detection thresholds
Yearly s-NfL increase and DPN risk
- Higher DPN risk per 1 ng/L/year higher yearly s-NfL increase, OR
- 1.36 (1.08; 1.71) (95% CI)
Original publication
Longitudinal Change in Serum Neurofilament Light Chain in Type 2 Diabetes and Early Diabetic Polyneuropathy: ADDITION-Denmark. Diabetes Care. Published 19 March 2024. doi:10.
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