Type 2 & other diabetes

Long-term weight change, incident cardiovascular disease and all-cause mortality among diabetic adults

Diabetes Res Clin PractPublished Cohort study

Authors' conclusion

Our findings indicated that the risk for incident CVD and all-cause mortality was potentially reinforced in diabetic adults who were obese at age 25 but non-obese at midlife and who remained stable obese vis-à-vis those with stable non-obesity.

Study context

Population
US diabetic adults aged 40–79 years, non-pregnant, with self-reported weight at age 25 and 10 years before baseline, National Health and Nutrition Examination Survey (NHANES) 1988–2018
Exposure
Weight change patterns from young (age 25) to middle adulthood vs stable non-obesity
Outcome
Incident CVD and all-cause mortality

Main finding

As reported in the abstract

Incident CVD · over following 10 years

Cardiovascular disease (CVD) cases averted if total population had maintained non-obese from young to middle adulthood

12 %

Observational data: associations, not effects.

Further findings

All-cause mortality

Increased risk with stable-obesity vs stable non-obesity

Original publication

Long-term weight change, incident cardiovascular disease and all-cause mortality among diabetic adults. Diabetes Res Clin Pract. Published 2 December 2024. doi:10.1016/j.diabres.2024.111946

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