Long-Term Glucocorticoid Exposure and Incident Cardiovascular Diseases—The Lifelines Cohort
Authors' conclusion
In this large, prospective cohort study, we found that long-term cortisone levels, measured in scalp hair, represent a relevant and significant predictor for future CVD in younger individuals. These results highlight glucocorticoid action as possible treatment target for CVD prevention, where hair glucocorticoid measurements could help identify individuals that may benefit from such treatments.
Study context
- Population
- Participants of the Lifelines cohort study with scalp hair samples analysed for cortisol and cortisone
- Participants
- 6,341 hair samples
- Exposure
- Hair glucocorticoid levels and incident cardiovascular diseases (CVD)
- Outcome
- Incident CVD
- Follow-up
- 5 to 7 years
Methodological detailspopulation-based cohort (Lifelines), logistic regression adjusted for classical cardiovascular risk factors, sensitivity analysis by age <60 and ≥60 years
- Population-based cohort (Lifelines)
- Logistic regression adjusted for classical cardiovascular risk factors
- Sensitivity analysis by age <60 and ≥60 years
Main finding
As reported in the abstract
- Hair cortisone levels independently associated with incident CVD
- P < .001
- Younger individuals: multivariate-adjusted OR per point increase in 10-log cortisone concentration [pg/mg]
- 4.21 (95% CI 1.91-9.07), P < .001
Observational data: associations, not effects.
Further findings
Immune parameters (total leukocytes and subtypes) and hair cortisone
- All immune parameters except eosinophils associated with hair cortisone
- all multivariate-adjusted P < .05
Original publication
Long-Term Glucocorticoid Exposure and Incident Cardiovascular Diseases—The Lifelines Cohort. J Clin Endocrinol Metab. Published 19 March 2024. doi:10.
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